Modeling Treatment Effect Modification in Multidrug-Resistant Tuberculosis in an Individual Patient Data Meta-Analysis
耐多药结核病个体患者数据元分析中的治疗效应修饰建模
Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine can be improved by identifying patient covariates to estimate the size and direction of the effect at the individual level. However, this task is statistically challenging and typically requires large amounts of data. Investigators may be interested in…