Causal effects on non-terminal event time with application to antibiotic usage and future resistance
非终末事件时间的因果效应:抗生素使用与未来耐药性
Comparing future antibiotic resistance levels resulting from different antibiotic treatments is challenging because some patients may survive only under one of the antibiotic treatments. We embed this problem within a semi-competing risks approach to study the causal effect on resistant infection, treated as a non-terminal event time. We argue that existing principal stratification estimands for such problems exclude patients for whom a causal effect is well-defined and is…