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目标试验模拟中有效统计推断的样本分割方法AI 解读

\noindent Target trial emulation has improved comparative effectiveness research by making the causal question, assumptions, and analysis plan explicit. However, target trial protocols are usually developed iteratively. That is, after examining the data, investigators revise the protocol to reflect which target trials the observational data can realistically support. This iterative procedure is part of normal scientific practice, but it raises concerns about selective…

标记点过程数据的因果推断AI 解读

We define dynamic treatment regimes and associated potential outcomes for data described by marked point processes (MPPs). These definitions motivate MPP analogues of the commonly used consistency, exchangeability, and positivity conditions that are sufficient for identifying effects in MPP data structures. The conditions are formulated based on martingale theory, which allows us to derive explicit identifying assumptions for data described by stochastic processes. The…

治疗依从性的可分离效应AI 解读

Comparing different medications is complicated when adherence to these medications differs. We can overcome the adherence issue by assessing effectiveness under sustained use, as in the usual causal `per-protocol' estimand. However, when sustained use is challenging to satisfy in practice, the usefulness of this estimand can be limited. Here we propose a different class of estimands: separable effects for adherence. These estimands compare modified medications, holding fixed…