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非信息先验对随机试验中贝叶斯比例优势模型的影响AI 解读

Background: Ordinal outcomes combine multiple distinct ordered patient states into a single endpoint and are commonly analysed using proportional odds (PO) models in clinical trials. When using a Bayesian approach, it is not obvious what the influence of a 'non-informative' prior is in the analysis of a fixed design or on early stopping decisions in adaptive designs. Methods: This study compares different non-informative prior specifications for the Bayesian PO model in the…

事件时间结局自适应临床试验设计的一般贝叶斯方法AI 解读

Clinical trials are an integral component of medical research. Trials require careful design to, for example, maintain the safety of participants, use resources efficiently and allow clinically meaningful conclusions to be drawn. Adaptive clinical trials (i.e. trials that can be altered based on evidence that has accrued) are often more efficient, informative and ethical than standard or non-adaptive trials because they require fewer participants, target more promising…