An adaptive enrichment design using Bayesian model averaging for selection and threshold-identification of tailoring variables
用贝叶斯模型平均选择个体化变量及识别阈值的自适应富集设计
Precision medicine stands as a transformative approach in healthcare, offering tailored treatments that can enhance patient outcomes and reduce healthcare costs. As understanding of complex disease improves, clinical trials are being designed to detect subgroups of patients with enhanced treatment effects. Biomarker-driven adaptive enrichment designs, which enroll a general population initially and later restrict accrual to treatment-sensitive patients, are gaining…