A statistical theory of graph regularization for RNA velocity near developmental bifurcations
发育分叉附近 RNA 速度图正则化的统计理论
Graph-based regularization is widely used to stabilize noisy RNA-velocity estimates by encouraging transcriptionally similar cells to share similar velocity vectors. Near developmental bifurcations, however, proximity-based graphs may connect cells from distinct daughter lineages, reducing estimation variance at the cost of attenuating biologically meaningful lineage-specific dynamics. We formulate graph-regularized RNA velocity as a statistical estimation problem on a…