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协变量数量发散时协变量自适应随机化的理论性质AI 解读

Covariate-adaptive randomization procedures are widely used in clinical trials to improve covariate balance. In modern applications, experimenters often have access to many covariates, motivating the need for a theory of covariate-adaptive randomization procedures with a diverging number of covariates. This paper studies two classes of covariate-adaptive randomization procedures, referred to as imbalance-efficient covariate-adaptive randomization and imbalance-robust…

平衡已观测与未观测协变量的多处理协变量自适应随机化：渐近性质AI 解读

Applications of CAR for balancing continuous covariates remain comparatively rare, especially in multi-treatment clinical trials, and the theoretical properties of multi-treatment CAR have remained largely elusive for decades. In this paper, we consider a general framework of CAR procedures for multi-treatment clinal trials which can balance general covariate features, such as quadratic and interaction terms which can be discrete, continuous, and mixing. We show that under…