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复发事件结局的双重稳健方法：降压治疗对急性肾损伤的因果效应AI 解读

Evaluating the average causal effects of treatment strategies on recurrent event outcomes, such as heart attacks or renal failure, is important in clinical and medical research. However, the analysis becomes increasingly complex as multiple interacting factors are considered within a longitudinal setting. In this paper, we use advanced methodologies to estimate the average causal effects of standard versus intensive blood pressure-lowering therapies on acute kidney injury…

将嵌套随机试验的条件平均处理效应推广至全部符合资格者AI 解读

Randomized controlled trials often enroll participants whose characteristics differ from those of a target population, which can limit the generalizability of the estimated treatment effects when effect modifiers differ across populations. While existing generalizability methods primarily focus on estimating the average treatment effect (ATE) in the target population, such summaries may obscure important heterogeneity that is relevant for clinical and policy decision-making.…

将右删失事件视作处理的讨论AI 解读

In causal inference literature, potential outcomes are often indexed by the "elimination of all right-censoring events," leading to the perception that such a restriction is necessary for defining well-posed causal estimands. In this paper, we clarify that this restriction is not required: a well-defined estimand can be formulated without indexing on the elimination of such events. Achieving this requires a more precise classification of right-censoring events than has…

目标研究缺少处理数据时的平均处理效应估计AI 解读

Researchers are frequently interested in understanding the causal effect of treatment interventions. However, in some cases, the treatment of interest--readily available in a randomized controlled trial (RCT)--is either not directly measured or entirely unavailable in observational datasets. This challenge has motivated the development of stochastic incremental propensity score interventions which operate on post-treatment exposures affected by the treatment of interest with…

暴露与混杂变量不完整时的平均因果效应估计AI 解读

Standard methods for estimating average causal effects require complete observations of the exposure and confounders. In observational studies, however, missing data are ubiquitous. Motivated by a study on the effect of prescription opioids on mortality, we propose methods for estimating average causal effects when exposures and potential confounders may be missing. We consider missingness at random and additionally propose several specific missing not at random (MNAR)…

存在未测混杂时中间变量的因果效应AI 解读

We present new results on average causal effects in settings with unmeasured exposure-outcome confounding. Our results are motivated by a class of estimands, e.g., frequently of interest in medicine and public health, that are currently not targeted by standard approaches for average causal effects. We recognize these estimands as queries about the average causal effect of an intervening variable. We anchor our introduction of these estimands in an investigation of the role…

统计因果推断中的解释性错误AI 解读

We formalize an interpretational error that is common in statistical causal inference, termed identity slippage. This formalism is used to describe historically-recognized fallacies, and analyse a fast-growing literature in statistics and applied fields. We conducted a systematic review of natural language claims in the literature on stochastic mediation parameters, and documented extensive evidence of identity slippage in applications. This framework for error detection is…

依赖观测处理过程的干预分布与因果生存分析中的模型双重稳健性AI 解读

The generalized g-formula can be used to estimate the probability of survival under a sustained treatment strategy. When treatment strategies are deterministic, estimators derived from the so-called efficient influence function (EIF) for the g-formula will be doubly robust to model misspecification. In recent years, several practical applications have motivated estimation of the g-formula under non-deterministic treatment strategies where treatment assignment at each time…