Instrumental Variable Approach to Estimating Individual Causal Effects in N-of-1 Trials: Application to ISTOP Study
N-of-1 试验中个体因果效应的工具变量估计:ISTOP 应用
An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advancements in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different…