Mixed Time Series Quasi-Likelihood Models for Uncovering Covid-19 Viral Load and Mortality Dynamics
混合类型时间序列拟似然模型:新冠病毒载量与死亡动态
Accurate real-time monitoring of disease transmission is crucial for epidemic control, which has conventionally relied on reported cases or hospital admissions. Such metrics are frequently susceptible to delays in reporting, various forms of bias, and under-ascertainment. Cycle threshold values obtained from reverse transcription quantitative polymerase chain reaction offer a promising alternative, serving as a proxy for viral load. In this paper, we aim to jointly model the…