Supervised Low-Rank Structure Discovery for Developmental Epigenetic Aging in Ultra-High-Dimensional DNA Methylation Data
超高维DNA甲基化数据中发育表观遗传衰老的监督低秩结构发现
Ultra-high-dimensional array-based CpG methylation studies require statistical frameworks that simultaneously provide supervised structure discovery, interpretability, scalable latent-dimension identification, and computational feasibility. We propose SOLAR (Supervised Orthogonal Low-rank Adaptive Regression), a supervised low-rank latent-factor framework for identifying CpG-level methylation structure associated with residualized DNAm age. SOLAR combines orthogonal low-rank…