Causal Vaccine Effects on Post-infection Outcomes in the Naturally Infected
自然感染人群中疫苗对感染后结局的因果效应
Understanding vaccine effects on post-infection outcomes is critical for evaluating the full value proposition of a vaccine. However, defining appropriate causal effects on such outcomes is challenging because infection is affected by vaccination. Existing approaches focus on the Doomed stratum, individuals who would be infected regardless of vaccine receipt. For many relevant outcomes, however, this estimand understates vaccine benefit by excluding individuals whose adverse…