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基于贝叶斯非参数联合模型的连续时间纵向与生存数据因果中介分析AI 解读

Observational cohort data is an important source of information for understanding the causal effects of treatments on survival and the degree to which these effects are mediated through changes in disease-related risk factors. However, these analyses are often complicated by irregular data collection intervals and the presence of longitudinal confounders and mediators. We propose a causal mediation framework that jointly models longitudinal exposures, confounders, mediators,…

半竞争风险的贝叶斯非参数方法及心血管健康应用AI 解读

We address causal estimation in semi-competing risks settings, where a non-terminal event may be precluded by one or more terminal events. We define a principal-stratification causal estimand for treatment effects on the non-terminal event, conditional on surviving past a specified landmark time. To estimate joint event-time distributions, we employ both vine-copula constructions and Bayesian nonparametric Enriched Dirichlet-process mixtures (EDPM), enabling inference under…

纵向中介与事件时间结局的贝叶斯半参数因果中介分析AI 解读

Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors. However, when analyzing data from a cohort study, such analyses are complicated by the longitudinal structure of the risk factors and the presence of time-varying confounders. Leveraging data from the Atherosclerosis Risk in Communities…