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从先验到表现：以贝叶斯动态借用提高统计效率AI 解读

One of the main advantages of the Bayesian approach to statistical inference is the flexibility in incorporating information from various sources, from expert opinion to historical data. Whereas the literature on Bayesian dynamic borrowing is rich, practical guidance for how to implement such methods is comparatively sparse. We thoroughly review the most common dynamic borrowing approaches for external data, including how to incorporate multiple historical data sets. We then…

含潜在变点的生存时间与纵向肿瘤负荷治愈率联合模型AI 解读

In non-small cell lung cancer (NSCLC) clinical trials, tumor burden (TB) is a key longitudinal biomarker for assessing treatment effects. Typically, standard-of-care (SOC) therapies and some novel interventions initially decrease TB; however, many patients subsequently experience an increase-indicating disease progression-while others show a continuous decline. In patients with an eventual TB increase, the change point marks the onset of progression and must occur before the…

借助随机效应潜在因子建模高效计算高维惩罚广义线性混合模型AI 解读

Modern biomedical datasets are increasingly high dimensional and exhibit complex correlation structures. Generalized Linear Mixed Models (GLMMs) have long been employed to account for such dependencies. However, proper specification of the fixed and random effects in GLMMs is increasingly difficult in high dimensions, and computational complexity grows with increasing dimension of the random effects. We present a novel reformulation of the GLMM using a factor model…

基于均值响应预测的广义线性模型层级先验AI 解读

There has been increased interest in using prior information in statistical analyses. For example, in rare diseases, it can be difficult to establish treatment efficacy based solely on data from a prospective study due to low sample sizes. To overcome this issue, an informative prior for the treatment effect may be elicited. We develop a novel extension of the conjugate prior of Chen and Ibrahim (2003) that enables practitioners to elicit a prior prediction for the mean…