Combining Real-World and Randomized Control Trial Data Using Data-Adaptive Weighting via the On-Trial Score
通过试验参与评分自适应加权整合真实世界与随机试验数据
Clinical trials with a hybrid control arm (a control arm constructed from a combination of randomized patients and real-world data on patients receiving usual care in standard clinical practice) have the potential to decrease the cost of randomized trials while increasing the proportion of trial patients given access to novel therapeutics. However, due to stringent trial inclusion criteria and differences in care and data quality between trials and community practice, trial…