Causal Estimation and Inference in Nonlinear Mendelian Randomization Studies
非线性孟德尔随机化研究中的因果估计与推断
Mendelian randomization (MR) is widely used to uncover causal relationships in the presence of unmeasured confounders. However, most existing MR methods presuppose linear causality, risking bias when the true relationships are nonlinear, which is a common empirical scenario. In this paper, we compared two prevalent instrumental variable techniques (the two-stage prediction method and the control function method) under both linear and nonlinear settings, and addressed key…