Robust and Data-Adaptive Integration of Nonconcurrent Data in Platform Trials via Gaussian Processes
通过高斯过程稳健、自适应地整合平台试验非同期数据
A platform trial is an innovative clinical trial design that enables simultaneous and continuous evaluation of multiple treatments within a single master protocol. Existing robust methods restrict analyses to concurrently randomized participants due to concerns that including nonconcurrent data may introduce bias from temporal trends. However, this exclusion represents a missed opportunity to improve efficiency. We propose a Gaussian process framework for incorporating…