Bias in multivariable Mendelian randomization studies due to measurement error on exposures
暴露测量误差导致的多变量孟德尔随机化偏倚
Multivariable Mendelian randomization estimates the causal effect of multiple exposures on an outcome, typically using summary statistics of genetic variant associations. However, exposures of interest in Mendelian randomization applications will often be measured with error. The summary statistics will therefore not be of the genetic associations with the exposure, but with the exposure measured with error. Classical measurement error will not bias genetic association…