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协变量不可忽略缺失下最优动态治疗方案的稳健估计AI 解读

Estimating optimal dynamic treatment regimes (DTRs) using observational data is often challenged by nonignorable missing covariates arsing from informative monitoring of patients in clinical practice. To address nonignorable missingness of pseudo-outcomes induced by nonignorable missing covariates, a weighted Q-learning approach using parametric Q-function models and a semiparametric missingness propensity model has recently been proposed. However, misspecification of…

非可忽略协变量缺失下优化动态治疗方案的加权 Q-learningAI 解读

Dynamic treatment regimes (DTRs) formalize medical decision-making as a sequence of rules for different stages, mapping patient-level information to recommended treatments. In practice, estimating an optimal DTR using observational data from electronic medical record (EMR) databases can be complicated by nonignorable missing covariates resulting from informative monitoring of patients. Since complete case analysis can provide consistent estimation of outcome model parameters…

混杂变量非随机缺失时因果效应的识别与估计AI 解读

Making causal inferences from observational studies can be challenging when confounders are missing not at random. In such cases, identifying causal effects is often not guaranteed. Motivated by a real example, we consider a treatment-independent missingness assumption under which we establish the identification of causal effects when confounders are missing not at random. We propose a weighted estimating equation (WEE) approach for estimating model parameters and introduce…

处理独立缺失假设下非随机缺失混杂变量的因果推断AI 解读

Causal inference in observational studies can be challenging when confounders are subject to missingness. Generally, the identification of causal effects is not guaranteed even under restrictive parametric model assumptions when confounders are missing not at random. To address this, We propose a general framework to establish the identification of causal effects when confounders are subject to treatment-independent missingness, which means that the missing data mechanism is…