Confidence Intervals for the Risk Difference in Combined Unilateral and Bilateral Data Incorporating a Distribution-Based Approach
结合分布方法的单侧与双侧混合数据风险差置信区间
Combined unilateral and bilateral binary outcomes frequently arise in studies involving paired organs. The risk difference is a clinically interpretable measure for comparing treatment effects between groups. Existing confidence interval methods are primarily based on asymptotic normality and may fail to adequately reflect finite-sample distributional features, particularly skewness. To address this issue, we propose a distribution-based confidence interval derived from the…