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借助外部数据稳健估计随机试验中的异质性处理效应AI 解读

Randomized trials are typically designed to detect average treatment effects but often lack the statistical power to uncover individual-level treatment effect heterogeneity, limiting their value for personalized decision-making. To address this, we propose the QR-learner, a model-agnostic learner that estimates conditional average treatment effects (CATE) within the trial population by leveraging external data from other trials or observational studies. The proposed method…

随机试验中外部对照数据的稳健整合AI 解读

One approach for increasing the efficiency of randomized trials is the use of "external controls" -- individuals who received the control treatment studied in the trial during routine practice or in prior experimental studies. Existing external control methods, however, can be biased if the populations underlying the trial and the external control data are not exchangeable. Here, we characterize a randomization-aware class of treatment effect estimators in the population…

风险评估的风险：用预测模型作治疗决策时的因果盲点AI 解读

Clinicians increasingly rely on prediction models to guide treatment choices. Most prediction models, however, are developed using observational data that include some patients who have already received the treatment the prediction model is meant to inform. Special attention to the causal role of those earlier treatments is required when interpreting the resulting predictions. We identify 'causal blind spots' in three common approaches to handling treatment when developing a…

通过检验因果机制独立性证伪无混杂假设AI 解读

A major challenge in estimating treatment effects in observational studies is the reliance on untestable conditions such as the assumption of no unmeasured confounding. In this work, we propose an algorithm that can falsify the assumption of no unmeasured confounding in a setting with observational data from multiple heterogeneous sources, which we refer to as environments. Our proposed falsification strategy leverages a key observation that unmeasured confounding can cause…

时变处理效应估计中的不规则测量时点：偏差分类与调整方法比较AI 解读

To estimate the causal effect of treatments that vary over time from observational data, one must adjust for time-varying confounding. A common procedure to address confounding is the use of inverse probability of treatment weighting methods. However, the timing of covariate measurements is often irregular, which may introduce additional confounding bias as well as selection bias into the causal effect estimate. Two reweighting methods have been proposed to adjust for these…

利用多个环境的观测数据检测隐藏混杂AI 解读

A common assumption in causal inference from observational data is that there is no hidden confounding. Yet it is, in general, impossible to verify this assumption from a single dataset. Under the assumption of independent causal mechanisms underlying the data-generating process, we demonstrate a way to detect unobserved confounders when having multiple observational datasets coming from different environments. We present a theory for testable conditional independencies that…