Clarifying the Role of the Mantel-Haenszel Risk Difference Estimator in Randomized Clinical Trials
厘清随机临床试验中 Mantel–Haenszel 风险差估计量的作用
The Mantel-Haenszel (MH) risk difference estimator, commonly used in randomized clinical trials for binary outcomes, calculates a weighted average of stratum-specific risk difference estimators. Traditionally, this method requires the stringent assumption that risk differences are homogeneous across strata, also known as the common (constant) risk difference assumption. In our article, we relax this assumption and adopt a modern perspective, viewing the MH risk difference…