Stable Transport Meta-Analysis for Heterogeneous Cardiovascular Trials: A Nuisance-Anchor Framework with a Sign-Stability Diagnostic
异质性心血管试验的稳定迁移元分析:干扰锚框架与符号稳定性诊断
Random-effects meta-analysis summarizes heterogeneous trials by estimating an average effect over the observed evidence base, which may not represent the clinically relevant target population. In cardiovascular medicine, treatment effects vary systematically across era, endpoint definitions, background therapy, and case-mix, making the historical average often misaligned with current decision-making. We propose stable transport meta-analysis (AMT-MA), a nuisance-anchor…