A joint longitudinal-survival framework for dynamic treatment regimen evaluation in sequential multiple assignment randomized trials
序贯多次随机分配试验中评估动态治疗方案的纵向—生存联合框架
Sequential multiple assignment randomized trials (SMARTs) provide a systematic framework for constructing and evaluating dynamic treatment regimens (DTRs). In clinical studies, longitudinal biomarkers are routinely collected to monitor disease progression and define treatment response. However, the integration of longitudinal biomarker data into survival analysis for DTR evaluation within a SMART remains unexplored. We propose a joint longitudinal-survival framework to…