Direct estimation and inference of higher-level correlations from lower-level measurements with applications in gene-pathway and proteomics studies
从低层级测量直接估计高层级相关性：基因通路与蛋白质组应用
This paper tackles the challenge of estimating correlations between higher-level biological variables (e.g., proteins and gene pathways) when only lower-level measurements are directly observed (e.g., peptides and individual genes). Existing methods typically aggregate lower-level data into higher-level variables and then estimate correlations based on the aggregated data. However, different data aggregation methods can yield varying correlation estimates as they target…