Robust Bayesian hierarchical models for basket trials enabling joint evaluation of toxicity and efficacy
联合评价毒性与疗效的稳健贝叶斯层级篮式试验模型
Basket trials have gained increasing attention for their efficiency, as multiple patient subgroups are evaluated simultaneously. Conducted basket trials focus primarily on establishing the early efficacy of a treatment, yet continued monitoring of toxicity is essential. In this paper, we propose two Bayesian hierarchical models that enable bivariate analyses of toxicity and efficacy, while accounting for heterogeneity present in the treatment effects across patient…