论文检索

连续处理后变量主层分析的贝叶斯非参数方法AI 解读

Principal stratification provides a causal inference framework for investigating treatment effects in the presence of a post-treatment variable. Principal strata play a key role in characterizing the treatment effect by identifying groups of units with the same or similar values for the potential post-treatment variable at all treatment levels. The literature has focused mainly on binary post-treatment variables. Few papers considered continuous post-treatment variables. In…

从加权视角理解空间回归：超级基金场地修复的观察性研究AI 解读

A key challenge in environmental health research is unmeasured spatial confounding, driven by unobserved spatially structured variables that influence both treatment and outcome. A common approach is to fit a spatial regression that models the outcome as a linear function of treatment and covariates, with a spatially structured error term to account for unmeasured spatial confounding. However, it remains unclear to what extent spatial regression actually accounts for such…

统一空间混杂处理方法的工具变量框架AI 解读

Studies investigating the causal effects of spatially varying exposures on outcomes often rely on observational and spatially indexed data. A prevalent challenge is unmeasured spatial confounding, where an unobserved spatially varying variable affects both exposure and outcome, leading to biased estimates and invalid confidence intervals. There is a very large literature on spatial statistics that attempts to address unmeasured spatial confounding bias; most of this…

环境暴露对社会流动的影响：主分层的贝叶斯半参数方法AI 解读

Understanding the causal effects of air pollution exposures on social mobility is attracting increasing attention. At the same time, education is widely recognized as a key driver of social mobility. However, the causal pathways linking fine particulate matter (PM2.5) exposure, educational attainment, and social mobility remain largely unexplored. To address this, we adopt the principal stratification approach, which rigorously defines causal effects when a post-treatment…

死亡存在时估计时变暴露对复发事件影响的结构嵌套率模型AI 解读

Assessing the causal effect of time-varying exposures on recurrent event processes is challenging in the presence of a terminating event. Our objective is to estimate both the short-term and delayed marginal causal effects of exposures on recurrent events while addressing the bias of a potentially correlated terminal event. Existing estimators based on marginal structural models and proportional rate models are unsuitable for estimating delayed marginal causal effects for…

SpaCE：空间混杂评测环境AI 解读

Spatial confounding poses a significant challenge in scientific studies involving spatial data, where unobserved spatial variables can influence both treatment and outcome, possibly leading to spurious associations. To address this problem, we introduce SpaCE: The Spatial Confounding Environment, the first toolkit to provide realistic benchmark datasets and tools for systematically evaluating causal inference methods designed to alleviate spatial confounding. Each dataset…

利用负向对照调整未测量混杂的贝叶斯非参数方法AI 解读

Unmeasured confounding bias threatens the validity of observational studies. While sensitivity analyses and study designs have been proposed to address this issue, they often overlook the growing availability of auxiliary data. Using negative controls from these data is a promising new approach to reduce unmeasured confounding bias. In this article, we develop a Bayesian nonparametric method to estimate a causal exposure-response function (CERF) leveraging information from…

利用神经网络估计暴露分布变化的因果效应AI 解读

A fundamental task in causal inference is estimating the effect of distribution shift in the treatment variable. We refer to this problem as shift-response function (SRF) estimation. Existing neural network methods for causal inference lack theoretical guarantees and practical implementations for SRF estimation. In this paper, we introduce Targeted Regularization for Exposure Shifts with Neural Networks (TRESNET), a method to estimate SRFs with robustness and efficiency…

利用混杂因素替代变量估计因果暴露反应曲线：空气污染与儿童健康AI 解读

In this paper, we undertake a case study to estimate a causal exposure-response function (ERF) for long-term exposure to fine particulate matter (PM$_{2.5}$) and respiratory hospitalizations in socioeconomically disadvantaged children using nationwide Medicaid claims data. These data present specific challenges. First, family income-based Medicaid eligibility criteria for children differ by state, creating socioeconomically distinct populations and leading to clustered data.…

观察性研究中处理效应估计的差异性回忆偏差AI 解读

Observational studies are frequently used to estimate the effect of an exposure or treatment on an outcome. To obtain an unbiased estimate of the treatment effect, it is crucial to measure the exposure accurately. A common type of exposure misclassification is recall bias, which occurs in retrospective cohort studies when study subjects may inaccurately recall their past exposure. Particularly challenging is differential recall bias in the context of self-reported binary…

混杂变量依赖的贝叶斯混合模型：空气污染因果效应的异质性AI 解读

Several epidemiological studies have provided evidence that long-term exposure to fine particulate matter (PM2.5) increases mortality risk. Furthermore, some population characteristics (e.g., age, race, and socioeconomic status) might play a crucial role in understanding vulnerability to air pollution. To inform policy, it is necessary to identify groups of the population that are more or less vulnerable to air pollution. In causal inference literature, the Group Average…

结合有偏与无偏因果估计的经验贝叶斯双重收缩AI 解读

Motivated by the proliferation of observational datasets and the need to integrate non-randomized evidence with randomized controlled trials, causal inference researchers have recently proposed several new methodologies for combining biased and unbiased estimators. We contribute to this growing literature by developing a new class of estimators for the data-combination problem: double-shrinkage estimators. Double-shrinkers first compute a data-driven convex combination of…

通过匹配估计因果分位数暴露响应函数AI 解读

We develop new matching estimators for estimating causal quantile exposure-response functions and quantile exposure effects with continuous treatments. We provide identification results for the parameters of interest and establish the asymptotic properties of the derived estimators. We introduce a two-step estimation procedure. In the first step, we construct a matched data set via generalized propensity score matching, adjusting for measured confounding. In the second step,…

环境流行病学中因果暴露反应曲线的贝叶斯高斯过程估计AI 解读

Motivated by environmental policy questions, we address the challenges of estimation, change point detection, and uncertainty quantification of a causal exposure-response function (CERF). Under a potential outcome framework, the CERF describes the relationship between a continuously varying exposure (or treatment) and its causal effect on an outcome. We propose a new Bayesian approach that relies on a Gaussian process (GP) model to estimate the CERF nonparametrically. To…

时间序列中随机干预的因果效应：高温预警能否减少死亡和住院？AI 解读

The methodological development of this paper is motivated by the need to address the following scientific question: does the issuance of heat alerts prevent adverse health effects? Our goal is to address this question within a causal inference framework in the context of time series data. A key challenge is that causal inference methods require the overlap assumption to hold: each unit (i.e., a day) must have a positive probability of receiving the treatment (i.e., issuing a…

病例对照研究中的回忆偏差：因果推断方法AI 解读

A case-control study is designed to help determine if an exposure is associated with an outcome. However, since case-control studies are retrospective, they are often subject to recall bias. Recall bias can occur when study subjects do not remember previous events accurately. In this paper, we first define the estimand of interest: the causal odds ratio (COR) for a case-control study. Second, we develop estimation approaches for the COR and present estimates as a function of…