Joint Model for Mediation Analysis with Causally Related Longitudinal and Recurrent Event Mediators for Survival Outcome
生存结局中具有因果关联的纵向与复发事件中介的联合模型
Recurrent events and repeated measures are commonly encountered in clinical longitudinal studies, often holding strong associations with patient outcomes. Although joint models for repeated measures, recurrent events, and a terminal event have been developed to account for their correlation, limited methodologies exist to examine causal mediation mechanisms involving multiple types of mediators, especially when mediators are causally related. This study addresses this gap by…