Modern Causal Inference Approaches to Improve Power for Subgroup Analysis in Randomized Controlled Trials
利用现代因果推断提高随机对照试验亚组分析的检验力
Randomized controlled trials (RCTs) often include subgroup analyses to assess whether treatment effects vary across pre-specified patient populations. However, these analyses frequently suffer from small sample sizes which limit the power to detect heterogeneous effects. Power can be improved by leveraging predictors of the outcome -- i.e., through covariate adjustment -- as well as by borrowing external data from similar RCTs or observational studies. The benefits of…