Can we detect treatment effect waning from time-to-event data?
能否从事件时间数据中识别处理效应衰减
Understanding how the causal effect of a treatment evolves over time, including the potential for waning, is important for informed decisions on treatment discontinuation or repetition. For example, waning vaccine protection influences booster dose recommendations, while cost-effectiveness analyses require accounting for long-term efficacy of treatments. However, there is no consensus on the methodology to assess and account for treatment effect waning. Even in randomized…