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基于负二项边际与高斯 Copula 的重复计数结局参照组敏感性分析AI 解读

Reference-based multiple imputation is used in longitudinal clinical trials to assess sensitivity to assumptions about outcomes unobserved after intercurrent events. Most existing methods target continuous outcomes and use multivariate normal working models. Scheduled count outcomes require a model that preserves integer support, skewness, overdispersion, longitudinal dependence, and an exposure-based rate interpretation. We propose visit-specific negative binomial (NB)…

利用伪观测进行协变量调整的限制平均生存时间贝叶斯分析AI 解读

The difference in restricted mean survival time (RMST) is a clinically meaningful measure to quantify treatment effect in randomized controlled trials, especially when the proportional hazards assumption does not hold. Several frequentist methods exist to estimate RMST adjusted for covariates based on modeling and integrating the survival function. A more natural approach may be a regression model on RMST using pseudo-observations, which allows for a direct estimation…