A burn-in(g) question: How long should an initial equal randomization stage be before Bayesian response-adaptive randomization?
贝叶斯响应自适应随机化之前的等概率随机分配阶段应多长？
Response-adaptive randomization (RAR) can increase participant benefit in clinical trials, but also complicates statistical analysis. The burn-in period (a non-adaptive initial stage) is commonly used to mitigate this disadvantage, yet guidance on its optimal duration is scarce. To address this critical gap, this paper introduces an exact evaluation approach to investigate how the burn-in length impacts statistical operating characteristics of two-arm binary Bayesian RAR…