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通过惩罚成对加速失效时间模型选择传染病传播变量AI 解读

In infectious disease transmission, regression and variable selection for time-to-event outcomes are complicated by transmission-induced dependence that violates standard independence assumptions. Pairwise survival analysis addresses this dependence by modeling contact intervals in ordered pairs, defined as the time from the onset of infectiousness in the pair's first individual to their first infectious contact with the second individual. We propose a penalized pairwise…

Rothman 图：关联度量修饰与可折叠性的几何解释AI 解读

Here, we outline how Rothman diagrams provide a geometric perspective that can help epidemiologists understand the relationships between effect measure modification (which we call association measure modification), collapsibility, and confounding. A Rothman diagram plots the risk of disease in the unexposed on the x-axis and the risk in the exposed on the y-axis. Crude and stratum-specific risks in the two exposure groups define points in the unit square. When there is…

多暴露与多样本情形下检测和控制选择偏差的图工具AI 解读

Among recent developments in definitions and analysis of selection bias is the potential outcomes approach of Kenah (Epidemiology, 2023), which allows non-parametric analysis using single-world intervention graphs, linking selection of study participants to identification of causal effects. Mohan & Pearl (JASA, 2021) provide a framework for missing data via directed acyclic graphs augmented with nodes indicating missingness for each sometimes-missing variable, which allows…

Rothman 图：流行病学因果推断的几何视角AI 解读

Here, we explain and illustrate a geometric perspective on causal inference in cohort studies that can help epidemiologists understand the role of standardization in causal inference as well as the distinctions between confounding, effect modification, and noncollapsibility. For simplicity, we focus on a binary exposure X, a binary outcome D, and a binary confounder C that is not causally affected by X. Rothman diagrams plot risk in the unexposed on the x-axis and risk in…

群组人群中传染病干预效应的因果识别AI 解读

Causal identification of treatment effects for infectious disease outcomes in interconnected populations is challenging because infection outcomes may be transmissible to others, and treatment given to one individual may affect others' outcomes. Contagion, or transmissibility of outcomes, complicates standard conceptions of treatment interference in which an intervention delivered to one individual can affect outcomes of others. Several statistical frameworks have been…