Beyond Fixed Restriction Time: Adaptive Restricted Mean Survival Time Methods in Clinical Trials
超越固定截断时间:临床试验中的自适应限制平均生存时间方法
Restricted mean survival time (RMST) offers a compelling nonparametric alternative to hazard ratios for right-censored time-to-event data, particularly when the proportional hazards assumption is violated. By capturing the total event-free time over a specified horizon, RMST provides an intuitive and clinically meaningful measure of absolute treatment benefit. Nonetheless, selecting the restriction time $L$ poses challenges: choosing a small $L$ can overlook late-emerging…