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随机临床试验中生存终点协变量调整的统一方法AI 解读

Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and standardized logistic regression for binary endpoints. For survival endpoints, while some covariate adjustment methods have been developed for specific effect measures, they are not commonly used in practice for various reasons, including…

随机临床试验中比例差的协变量调整与估计AI 解读

Difference in proportions is frequently used to measure treatment effect for binary outcomes in randomized clinical trials. The estimation of difference in proportions can be assisted by adjusting for prognostic baseline covariates to enhance precision and bolster statistical power. Standardization or G-computation is a widely used method for covariate adjustment in estimating unconditional difference in proportions, because of its robustness to model misspecification.…