Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization
利用多变量孟德尔随机化分离共享聚集遗传预测因子的性状效应
When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines. Associations between variants in this cluster and stroke risk may be driven by any of these cytokines. Multivariable Mendelian randomization is an extension of standard univariable Mendelian randomization…