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病例对照研究中基于倾向得分的因果推断AI 解读

Propensity score methods for causal inference are increasingly being used in cohort and experimental designs, but their development and uptake in outcome-dependent sampling schemes, such as case-control studies, remains limited. Case-control studies involve the sampling of individuals with and without an outcome of interest with the goal of estimating the effects of past exposures. When the design is observational, statistical adjustment for confounding bias is necessary. In…

因果中介分析中的正值性假设检查AI 解读

Causal mediation analyses are increasingly used in psychological sciences. Among the required assumptions, positivity is unfortunately seldom mentioned, likely due to the lack of tools for checking it. Mediational positivity is more complex than positivity in standard, non-mediated exposure effect analysis, because it requires positivity for both the exposure and the mediator, and because the specific form of the positivity assumption depends on the mediation estimand of…

非参数因果图模型中时变处理效应估计的高效调整集AI 解读

Criteria for identifying optimal adjustment sets yielding consistent estimation with minimal asymptotic variance of average treatment effects in parametric and nonparametric models have recently been established. In a single treatment time point setting, it has been shown that the optimal adjustment set can be identified based on a causal directed acyclic graph alone. In a time-dependent treatment setting, previous work has established graphical rules to compare the…

纵向因果推断中治疗模型的自适应稀疏化与平滑AI 解读

Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a novel two-step procedure for variable selection when modeling the treatment probability at each time point. We first introduce a novel approach to longitudinal confounder selection using a Longitudinal Outcome Adaptive LASSO (LOAL) that…

检测阴性设计下评估新冠疫苗有效性的双重机器学习方法AI 解读

The test-negative design (TND), which is routinely used for monitoring seasonal flu vaccine effectiveness (VE), has recently become integral to COVID-19 vaccine surveillance, notably in Québec, Canada. Some studies have addressed the identifiability and estimation of causal parameters under the TND, but efficiency bounds for nonparametric estimators of the target parameter under the unconfoundedness assumption have not yet been investigated. Motivated by the goal of…