The Win Ratio at the Design Stage of Clinical Trials
临床试验设计阶段的胜率比
The win ratio offers a flexible approach to incorporate the hierarchy of clinical outcomes into the analysis of a composite endpoint, enabling simultaneous consideration of multiple outcome types, unlike traditional time-to-first-event (TTFE) analysis or focus on a single outcome. We examined the statistical power of the win ratio compared to single-endpoint analyses and TTFE analysis through a case study and simulation studies. Furthermore, we provide a novel formula to…