Leveraging external data in the analysis of randomized controlled trials: a comparative analysis
随机对照试验分析中利用外部数据的方法比较
The use of patient-level information from previous studies, registries, and other external datasets can support the analysis of single-arm and randomized controlled trials to evaluate and test experimental treatments. However, the integration of external data in the analysis of clinical trials can also compromise the scientific validity of the results due to selection bias, study-to-study differences, unmeasured confounding, and other distortion mechanisms. Therefore,…