Regression-Based Proximal Reconciliation of Conflicting Trials with Unmeasured Effect Modifiers
存在未观测效应修饰变量时冲突试验的回归式近端协调
Randomized controlled trials with similar protocols may yield conflicting findings when the distribution of relevant effect modifiers differs across study populations. Yet no formal statistical framework exists for defining and assessing whether conflicting trials are reconcilable, despite the importance of this question for evidence synthesis and regulatory decision making. To address this gap, we develop a causal inference framework for evaluating conditional and marginal…