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Causal Falsification of Digital Twins

数字孪生的因果证伪

Digital twins are simulation-based models designed to predict how a real-world process will evolve in response to interventions. This modelling paradigm holds substantial promise in many applications, but rigorous procedures for assessing their accuracy are essential for safety-critical settings. We consider how to assess the accuracy of a digital twin using real-world data. We formulate this as a causal inference problem, which leads to a precise definition of what it means…

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Deconfounding Scores and Representation Learning for Causal Effect Estimation with Weak Overlap

弱重叠下因果效应估计的去混杂得分与表示学习

Overlap, also known as positivity, is a key condition for causal treatment effect estimation. Many popular estimators suffer from high variance and become brittle when features differ strongly across treatment groups. This is especially challenging in high dimensions: the curse of dimensionality can make overlap implausible. To address this, we propose a class of feature representations called deconfounding scores, which preserve both identification and the target of…

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Towards Representation Learning for Weighting Problems in Design-Based Causal Inference

面向设计型因果加权问题的表征学习

Reweighting a distribution to minimize a distance to a target distribution is a powerful and flexible strategy for estimating a wide range of causal effects, but can be challenging in practice because optimal weights typically depend on knowledge of the underlying data generating process. In this paper, we focus on design-based weights, which do not incorporate outcome information; prominent examples include prospective cohort studies, survey weighting, and the weighting…

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Hierarchical Bias-Driven Stratification for Interpretable Causal Effect Estimation

用于可解释因果效应估计的分层偏差驱动分层方法

Interpretability and transparency are essential for incorporating causal effect models from observational data into policy decision-making. They can provide trust for the model in the absence of ground truth labels to evaluate the accuracy of such models. To date, attempts at transparent causal effect estimation consist of applying post hoc explanation methods to black-box models, which are not interpretable. Here, we present BICauseTree: an interpretable balancing method…

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Semiparametric posterior corrections

半参数后验校正

We present a new approach to semiparametric inference using corrected posterior distributions. The method allows us to leverage the adaptivity, regularization and predictive power of nonparametric Bayesian procedures to estimate low-dimensional functionals of interest without being restricted by the holistic Bayesian formalism. Starting from a conventional nonparametric posterior, we target the functional of interest by transforming the entire distribution with a Bayesian…

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Causal predictive inference and target trial emulation

因果预测推断与目标试验模拟

Causal inference from observational data can be viewed as a missing data problem arising from a hypothetical population-scale randomized trial matched to the observational study. This links a target trial protocol with a corresponding generative predictive model for inference, providing a complete framework for transparent communication of causal assumptions and statistical uncertainty on treatment effects, without the need for counterfactuals. The intuitive foundation for…

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