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预期高安慰剂反应时安慰剂对照随机试验的因果效应估计AI 解读

In placebo-controlled randomized clinical trials (RCTs), the placebo response significantly modifies treatment effects and diminishes the intention-to-treat (ITT) treatment effect, $Δ_{ITT}$. This study presents a novel two-stage framework for estimating the standardized causal treatment effect, $Δ_{STD}$, among the ITT population, under the assumption that their placebo responses are similar to the levels of self-administering medication at home. The first stage employs a…

基于中介相关引导贝叶斯变量选择的高维广义线性模型中介分析AI 解读

High-dimensional mediation analysis aims to identify mediating pathways and to estimate indirect effects linking an exposure to an outcome. In this paper, we propose a Bayesian framework to address key challenges in these analyses, including high dimensionality, complex dependence among omics mediators, and non-continuous outcomes. Furthermore, commonly used approaches assume independent mediators or ignore correlations in the selection stage, which can reduce power when…

高维中介分析的贝叶斯变量选择：流行病学代谢组数据应用AI 解读

In epidemiological research, causal models incorporating potential mediators along a pathway are crucial for understanding how exposures influence health outcomes. This work is motivated by integrated epidemiological and blood biomarker studies, investigating the relationship between long-term adherence to a Mediterranean diet and cardiometabolic health, with plasma metabolomes as potential mediators. Analyzing causal mediation in such high-dimensional omics data presents…

用于主分层因果效应的贝叶斯非参数树模型AI 解读

Principal stratification analysis evaluates how causal effects of a treatment on a primary outcome vary across strata of units defined by their treatment effect on some intermediate quantity. This endeavor is substantially challenged when the intermediate variable is continuously scaled and there are infinitely many basic principal strata. We employ a Bayesian nonparametric approach to flexibly evaluate treatment effects across flexibly-modeled principal strata. The approach…

混杂调整的贝叶斯非参数方法AI 解读

Analysis of observational studies increasingly confronts the challenge of determining which of a possibly high-dimensional set of available covariates are required to satisfy the assumption of ignorable treatment assignment for estimation of causal effects. We propose a Bayesian nonparametric approach that simultaneously 1) prioritizes inclusion of adjustment variables in accordance with existing principles of confounder selection; 2) estimates causal effects in a manner…