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MR-CCC：细胞间因果通信的贝叶斯孟德尔随机化AI 解读

Cell--cell communication (CCC) is commonly inferred from ligand--receptor co-expression, an associational paradigm that cannot distinguish causal signaling from shared regulation or confounding. We propose MR-CCC, a Bayesian Mendelian randomization framework that uses cis-eQTLs as instruments for ligand and receptor expression and explicitly models receptor-modulated ligand effects through an interaction term, so the causal effect of a ligand can vary with receptor…

基于相关误差贝叶斯有向循环图模型的多变量双向孟德尔随机化AI 解读

Mendelian randomization (MR) is a pivotal tool in genetics, genomics, and epidemiology, leveraging genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. Traditional MR methods, while powerful, often rely on stringent assumptions such as the absence of feedback loops, which are frequently violated in complex biological networks. In addition, many popular MR approaches focus on only two variables (i.e., one exposure and one…