Weighted hazard ratio estimation for delayed and diminishing treatment effect
延迟及递减处理效应下的加权风险比估计
Non-proportional hazards (NPH) have been observed in confirmatory clinical trials with time to event outcomes. Under NPH, the hazard ratio does not stay constant over time and the log-rank test is no longer the most powerful test. The weighted log-rank test (WLRT) has been introduced to deal with the presence of non-proportionality. We focus our attention on the WLRT and the complementary Cox model based on the time-varying treatment effect proposed by Lin and León (2017)…