An extension to reversible jump Markov chain Monte Carlo for change point problems with heterogeneous temporal dynamics
面向异质时间动态变点问题的可逆跳跃 MCMC 扩展
Detecting brief changes in time-series data remains a major challenge in fields where short-lived states carry meaning. In single-molecule localisation microscopy, this problem is particularly acute as fluorescent molecules used to tag protein oligomers display heterogenous photophysical behaviour that can complicate photobleach step analysis; a key step in resolving nanoscale protein organisation. Existing methods often require extensive filtering or prior calibration, and…