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固定簇内重复抽取不同个体以提高纵向估计精度：DISC 设计AI 解读

Background: Longitudinal studies often involve repeated cluster sampling of a population at multiple time points, such as in difference-in-differences (DID) studies. Although cohort designs typically lead to more efficient estimators relative to repeated cross-sectional (RCS) designs, they are often impractical. Methods: We describe the DISC (Different Individuals, Same Clusters) design, a sampling scheme that improves the precision of estimators in these settings. The DISC…

处理效应随时间变化时阶梯楔形试验检验功效的影响因素AI 解读

Stepped wedge cluster randomized trials (SW-CRTs) have historically been analyzed using immediate treatment (IT) models, which assume the effect of the treatment is immediate after treatment initiation and subsequently remains constant over time. However, recent research has shown that this assumption can lead to severely misleading results if treatment effects vary with exposure time, i.e. time since the intervention started. Models that account for time-varying treatment…

处理效应随暴露时间或日历时间变化时的阶梯楔形整群随机试验分析AI 解读

Stepped-wedge cluster randomized trials (SW-CRTs) are traditionally analyzed with models that assume an immediate and sustained treatment effect. Previous work has shown that making such an assumption in the analysis of SW-CRTs when the true underlying treatment effect varies by exposure time can produce severely misleading estimates. Alternatively, the true underlying treatment effect might vary by calendar time. Comparatively less work has examined treatment effect…

处理效应随暴露时间变化时的阶梯楔形整群随机试验分析AI 解读

Stepped wedge cluster randomized controlled trials are typically analyzed using models that assume the full effect of the treatment is achieved instantaneously. We provide an analytical framework for scenarios in which the treatment effect varies as a function of exposure time (time since the start of treatment) and define the "effect curve" as the magnitude of the treatment effect on the linear predictor scale as a function of exposure time. The "time-averaged treatment…