A general Bayesian approach to design adaptive clinical trials with time-to-event outcomes
事件时间结局自适应临床试验设计的一般贝叶斯方法
Clinical trials are an integral component of medical research. Trials require careful design to, for example, maintain the safety of participants, use resources efficiently and allow clinically meaningful conclusions to be drawn. Adaptive clinical trials (i.e. trials that can be altered based on evidence that has accrued) are often more efficient, informative and ethical than standard or non-adaptive trials because they require fewer participants, target more promising…