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孟德尔随机化因果推断方法：估计对象、识别与推断AI 解读

Mendelian randomization (MR) has become an essential tool for causal inference in biomedical and public health research. By using genetic variants as instrumental variables, MR helps address unmeasured confounding and reverse causation, offering a quasi-experimental framework to evaluate causal effects of modifiable exposures on health outcomes. Despite its promise, MR faces substantial methodological challenges, including invalid instruments, weak instrument bias, and…

兼顾连锁不平衡与特异性多效性的两样本稳健贝叶斯孟德尔随机化AI 解读

Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample MR methods based on genome-wide association study summary level data, however, those methods could suffer from potential power loss or/and biased inference when the chosen genetic variants are in linkage disequilibrium (LD), and also have…