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用于组学数据的通路引导贝叶斯因子模型AI 解读

Interpreting RNA-sequencing data requires identifying coordinated gene expression patterns that correspond to biological pathways. Standard factor models provide useful dimension reduction but typically ignore existing pathway knowledge or incorporate it through restrictive assumptions, limiting interpretability, and reproducibility. Here, we develop Bayesian Analysis with gene-Sets Informed Latent space (BASIL), a scalable framework for analyzing transcriptomic data that…

可识别且可解释的非参数因子分析AI 解读

Factor models are widely used to reduce dimensionality in modeling high-dimensional data. However, there remains a need for models that can be reliably fit in modest sample sizes and are identifiable, interpretable, and flexible. To address this gap, we propose a NIFTY model that uses a linear factor structure with Gaussian residuals, but with a novel latent variable modeling structure. In particular, we model each latent variable as a one-dimensional nonlinear mapping of a…