Flexible evaluation of surrogacy in Bayesian adaptive platform studies
贝叶斯自适应平台研究中替代终点的灵活评价
Trial level surrogates are useful tools for improving the speed and cost effectiveness of trials, but surrogates that have not been properly evaluated can cause misleading results. The evaluation procedure is often contextual and depends on the type of trial setting. There have been many proposed methods for trial level surrogate evaluation, but none, to our knowledge, for the specific setting of Bayesian adaptive platform studies. As adaptive studies are becoming more…